CASP3 and neoplasm: When compared to the tumor tissues from the vehicle treated group, tumor tissues from the 25-mg/kg sHA-F treatment group (i.e. Group 1) showed increased levels of cleaved PARP, activated caspase – 3, 8, DR4, Fas, E-cadherin and pβ-Cateinin(T41/S45), but a decrease in Bcl-2, pAKT, pGSK-3α/β, β-Cateinin, pβ-Cateinin(S552) levels (Figure 7C).