This analysis revealed upregulation of protein levels of glyceraldehyde-phosphate-dehydrogenase (GAPDH), phosphoglycerate kinase (PGK1), ENO2, pyruvate kinase (PKM2), and LDH-A in RCC specimens (n = 40) as compared to normal tissue [15]. The gene discussed is LDHA; the disease is renal cell adenocarcinoma.