Through studies it has been shown that inhibition of Cdh1 can lead to centrosome amplification and incorrect chromosome segregation, and thus has been associated with genetic instability and tumorigenesis, Cdh1 deficient (Fzr1+/−) mice develop several types of epithelial tumors, such as fibroadenomas and mammary gland adenocarcinomas, which are not observed in Cdh1 wild-type (Fzr1+/+) mice [91]. This evidence concerns the gene FZR1 and Fibroadenoma.