In addition, CALB2 (calbindin 2) or calretinin, MAPRE2 (microtubule-associated protein, RP/EB family, member 2), RNASE1 (ribonuclease, RNase A family, 1), ESRRG or estrogen related receptor gamma, MAPK8 (mitogen-activated protein kinase 8) and PCMT1 (protein-L-isoaspartate (D-aspartate) O-methyltransferase) which are involved in various cellular processes have been reported to be associated with a more invasive cancer phenotype. The gene discussed is RNASE1; the disease is cancer.