MADD and melanoma: Among the significantly upregulated genes, MIA (melanoma inhibitory activity), KLK13 (kallikrein-related peptidase 13), HEPACAM (hepatic and glial cell adhesion molecule), MADD (MAP-kinase activating death domain), TP53I11 (tumor protein p53 inducible protein 11), based on the importance of their cellular localization have been reported as being associated with a more invasive cancer phenotype.