ADIPOQ and metabolic disease: Adiponectin (APN, also known as adipocyte complement-related protein of 30 kD, adipoQ, apM1, and GBP28) is an adipokine secreted by adipose tissues and other cells, including cardiomyocytes12, whose expression levels are negatively correlated with cerebrovascular, cardiovascular and metabolic diseases, indicating an important role of adiponectin in the cardiovascular system13, 14, 15, 16.