IGF1 and chondrosarcoma: Treating our full chondrosarcoma cell line panel for 72 h with concentrations from 0.01 to 1000 nM of OSI-906 revealed that chondrosarcoma cell viability was not affected by inhibition of the IGF pathway, whereas the positive control cell line TC-32 (Ewing sarcoma) showed dose-dependent decrease of cell viability (Fig. 2a).