Using receiver operating characteristic (ROC) analyses to determine the highest sensitivity and specificity values that could be obtained, we set the serum MMP1 level to 15 ng/mL as the cutoff for ADPKD patients to indicate the likelihood of having ICAs (odds ratio (95% CI); 2.031 (1.260–3.274); P = 0.0036; Tables 2 and S9). The gene discussed is MMP1; the disease is autosomal dominant polycystic kidney disease.