PKD1 and autosomal dominant polycystic kidney disease: While vascular smooth muscle cells from Pkd1+/− and Pkd2+/− mouse aortas showed a statistically significant decrease in the resting [Ca2+]i levels and agonist-induced Ca2+ release in previous studies24, 25, 27, 39, 40, 41, we found human vascular cells derived from ADPKD-specific iPSCs did not.