Abnormal intracellular Ca2+ handling was detected in vascular smooth muscle cells from Pkd1+/− and Pkd2+/− mouse aortas, renal collecting duct cells from Pkd1+/− mice and renal cyst cells from ADPKD patients24, 25, 27, 39, 40, 41. The gene discussed is PKD1; the disease is Renal cyst.