MMP1 and familial isolated congenital asplenia: Family history of ICAs or SAH, which is reported to be risk factors for the complication of ICAs in ADPKD, sex (female), which is a known to be a risk factor for ICAs in the generalized population, and serum MMP1 level were significantly associated with the complication of ICAs in ADPKD in our clinical study (Table 2)44, 45.