CXCR4 and cancer: Given the apparent pivotal role of CXCR4 in inducing EMT and metastases in NETs (manuscript submitted), and the robust epigenetic regulation of the CXCL12/CXCR4 axis in cancer [83], future work should determine if complex NET epigenetic profiles and resulting patterns of biologic malignancy as well as clinical outcomes may be recapitulated, at least in part, by CXCR4 expression.