Previously we have shown that cambogin induces breast adenocarcinoma cell apoptosis via ROS-mediated increases in Bax/Bcl-2 ratio and the nuclear import of apoptosis inducing factor (AIF), in parallel with the stimulation of ASK1-MKK4/MKK7-JNK/SAPK signaling cascade [21]. This evidence concerns the gene MAPK8 and breast adenocarcinoma.