CEACAM5 and metastatic malignant neoplasm: Our study also shows that CRC exosomes up-regulate the expression of two cell markers in cMSCs: vacuolar H+-ATPase (V-ATPase) is considered a surrogate tumor marker, overexpressed in many metastatic cancers [49] but also a target of new anti-cancer therapies [50, 51], and CEA is a typical tumor marker [39], used worldwide for colon cancer follow up and screening.