SOX2 and lung cancer: In this study, we analyzed the differentiation status and dedifferentiation status of human lung cancer cells at the single cell level and showed that some lung differentiated MP cells dedifferentiate into CSCs/CICs-like SP cells in short-term culture with relative high expression level of SOX2. Our data suggest that human lung cancer cells have plasticity by which lung differentiated non-CSCs/CICs can dedifferentiate into CSCs/CICs in vitro.