We and another group reported the detection of ALK-rearrangement in CTCs ISET-enriched by filtration in NSCLC patients with an ALK-rearranged tumor [17, 18, 35] as well ROS1-rearrangement in CTCs from NSCLC patients with an ROS1-rearranged tumor [20]. The gene discussed is ROS1; the disease is non-small cell lung carcinoma.