Unlike the general population, in this setting, where the population (i.e. insulin resistance, obesity, prediabetes, metabolic syndrome, high TG levels, low HDL-C levels, T2DM) is enriched with unfavorable discordance, apo B or LDL-P concentrations are much more predictive as biomarkers of ASCVD risk [4, 13, 14, 16, 24, 25]. Here, APOB is linked to atherosclerosis.