Those mice that were Cyp27b1 (−/−) showed decreased IL-10 in the proximal colon and Toll-like receptors 2 and 4 in the distal colon as well as decreased levels of circulating 1,25(OH)2VitD, thus implicating vitamin D affecting colitis in DSS‐treated mice [56]. The gene discussed is CYP27B1; the disease is colitis.