BRCA1 and breast carcinoma: Risk factors for breast cancer include family history of breast or ovarian cancer, mutations in major breast cancer-causing genes (e.g., BRCA1 and BRCA2; BRCA1/2), and Central or Eastern European Jewish heritage (primarily Ashkenazi Jewish descent), radiation therapy to the breast or chest at a young age, as well as other breast health conditions or dense breasts [2].