We observed significant associations between MDM2 amplification and increased CRC risk (amp v.s. wt: ORadjusted = 14.37, 95% CI: 1.27, 163.74, P = 0.032; amp v.s. del + wt: ORadjusted = 14.40, 95% CI: 1.26, 164.81, P = 0.032). Here, MDM2 is linked to colorectal carcinoma.