The CEA and CA19-9 level before surgery, Dukes stage, pathological type and metastasis were adjusted for in the analysis of FBXW7, MDM2, SKP2, β-TRCP and NEDD4-1 CNVs and CRC prognosis, due to their significant association with CRC prognosis in the univariate Cox proportional hazards regression. The gene discussed is SKP2; the disease is colorectal carcinoma.