TRPM8 and melanoma: Another member of the TRPM family, TRPM8, was shown to be functionally expressed in melanoma cells with sustained Ca2+ influx mediated by the channel agonist menthol leading to decreased viability of cells (Yamamura et al., 2008), although TRPM8 is also involved in normal melanocyte physiology so the extent to which this phenomenon is specific to melanoma is not clear.