Moreover, in mice Tregs are sufficient to diminish the allergy response [49], likely through secretion of the inhibitory molecules such as glucocorticoid-induced TNFR (Tumor necrosis factor receptor) family related gene (GITR), CTLA4 (cytotoxic T-lymphocyte-associated protein 4) [50], TGF-β, and IL-10 [51] and the downregulation of pro-effector T cell cytokines such as IL-2 [52,53,54,55]. Here, CTLA4 is linked to allergic disease.