AKT1 and tuberous sclerosis: Furthermore, by exploring the cell growth pathways such as through TSC-mTOR and PI3K-AKT signalling65, as well as the integrated stress response signalling that controls cell survival and death, it may be possible to design a strategy to promote survival of OLs and myelin repair in patients with TSC or, perhaps, the devastating central demyelinating diseases such as multiple sclerosis.