Previous studies demonstrated that the phosphatidyl inositol 3‐kinase–Akt signaling pathway protects the heart against injuries and is therefore called a survival factor for cardiomyocytes; however, this pathway also induces cardiac hypertrophy (Fujio et al., 2000; Condorelli et al., 2002; Zhao et al., 2015). Here, AKT1 is linked to cardiac hypertrophy.