To determine the functional significance of DENV2 NS1-triggered disruption of Sia in the EGL, sialidase activity was inhibited using Zanamivir, an influenza neuraminidase inhibitor that has been shown to significantly inhibit Neu2 and Neu3 [19], and 2-deoxy-2,3-didehydro-N-acetyl-neuraminic acid (DANA), a transition state analog inhibitor of influenza virus neuraminidase found to be active against mammalian Neu3 [20]. The gene discussed is NEU2; the disease is influenza.