Consistent with our observations, previous studies also indicated that FHL2 facilitates cell migration in osteosarcoma and glioblastoma.27, 40 Moreover, our observations are consistent with results from FHL2-deficient mice, in which cutaneous wound healing was impaired.41 Since the contribution of tumor cell motility to metastasis has been well documented,42 overexpressed FHL2 in GCTs may also contribute to the metastasis of human GCT. The gene discussed is FHL2; the disease is osteosarcoma.