The role of FHL2 in cancer is particularly intriguing because it functions as an oncogenic protein or a tumor suppressor.22 FHL2 acts as an oncogene in breast cancer,23 gastric and colon cancer,24, 25 prostate cancer,15, 19, 26 and glioblastoma.27 On the contrary, FHL2 has also been identified as a tumor suppressor in human rhabdomyosarcoma,20 hepatocellular carcinoma,28 neuroblastoma29 and a sub-type of breast cancer.30 The exact mechanism underlying its differential actions in different type of cancers is unclear. This evidence concerns the gene FHL2 and colonic neoplasm.