TGFB1 and malignant colon neoplasm: Previous studies indicate that the role of FHL2 in cell proliferation is tissue and cell type specific.28, 36, 37, 38 For example, FHL2 inhibits anchorage-dependent and -independent growth of hepatocellular carcinoma cells through a TGFß-like signaling pathway.28 On the other hand, FHL2 acts as a TGFβ1-responsive gene and promotes colon cancer cell adhesion, migration and invasion.36 Although FHL2 expression in the normal ovary32 and ovarian cancer31 has been reported, its role in the ovarian tumorigenesis has not been reported.