Conversely, when we inhibit GPRC5A in pancreatic cancer cell lines such as MIA PaCa-2, Panc-1 and Capan-2 (Figures 3e and h and Supplementary Figures S2E–G and S3A–D) and in normal pancreatic cell line such as hTERT-HPNE (Supplementary Figures 3E–H) we decrease the cells' ability to form colonies and we hinder migration. Here, GPRC5A is linked to familial pancreatic carcinoma.