Gemcitabine treatment could induce apoptosis in pancreatic cancer cells (Supplementary Figures S9A and B) that was enhanced when we inhibited GPRC5A with an siRNA (Supplementary Figures S9A and B, Figures 4a–c and Supplementary Figures S4A–H). The gene discussed is GPRC5A; the disease is familial pancreatic carcinoma.