Having established that across all cancers GPRC5A is very abundant in pancreatic cancer, we analyzed previously reported microarray data2 (GEO accession number: GSE71729) and examined GPRC5A expression in normal pancreatic tissue (n=46), primary pancreatic tumors (n=145) and metastatic tumors (n=61) using the R statistical computing environment.58Figure 1c shows that compared with normal pancreas, GPRC5A is upregulated in primary tumors (P-value <10−5) and in pancreatic metastases (P-value=0.0021). Here, GPRC5A is linked to familial pancreatic carcinoma.