This is further corroborated by previous reports of GPRC5A acting as a tumor suppressor in lung24 whereas in, for example, stomach and liver, increased GPRC5A levels are associated with poor prognosis in patients with gastric cancer or hepatocellular carcinoma, respectively.20, 26 In pancreas, previous research showed that GPRC5A was upregulated in the cancer state,6 but studies of its roles in pancreatic cancer have been limited. This evidence concerns the gene GPRC5A and hepatocellular carcinoma.