Our further analyses of GPRC5A on MIA PaCa-2 cells' response to gemcitabine showed that knockdown of GPRC5A enhanced cell apoptosis without gemcitabine treatment; also, that administration of gemcitabine further enhanced pancreatic cancer cell apoptosis (Supplementary Figures S9A and B). This evidence concerns the gene GPRC5A and familial pancreatic carcinoma.