HNRNPA1 and amyotrophic lateral sclerosis: In this work, computational biology methods were applied, following the methodology previously described by our group [10,11], to an in silico analysis of hnRNPA1 protein, which has been described as the cause of familial Amyotrophic Lateral Sclerosis type 20, aiming for a thorough analysis of the protein structure and its natural variants, as well as the effects of structural changes in the disease development.