However, there was neither significant relationship between KIR2DL4 genotype and the prevalence of atopy, as assessed by allergen skin prick testing in either cohort at any age, nor was there any significant relationship between KIR2DL4 genotype and the prevalence of wheeze, bronchial hyperreactivity, and asthma. The gene discussed is KIR2DL4; the disease is asthma.