In addition, TLR2, a pattern recognition receptor for LTA from S. aureus or LPS from P. gingivalis, is prominently expressed in the pocket epithelium of periodontal tissues with chronic periodontitis and participated in the signaling cascade to upregulate the production of IL-8 [13, 15–17, 19, 20]. This evidence concerns the gene CXCL8 and periodontitis.