Specific alleles of BLM have been associated with human cancers: BLM P868L (rs11852361) with colorectal cancer (odds ratio = 1.29, 95% CI, 1.02–1.64: p = 0.04) and BLM rs2532105 with breast cancer (odds ratio = 2.0, 95% CI: 1.2–3.3, p ≤ 0.05), respectively [153, 166]. The gene discussed is BLM; the disease is cancer.