Compared to C57Bl/6J ApcMin/+ mice, mice on a mixed C57Bl/AKR background have a reduced tumor burden of 6.0 ± 4.7 polyps [62]. Mom1, the first reported modifier of Min, is predominantly responsible for the observed phenotype [63, 64]. Mom1 was subsequently identified as phospholipase A2 (Pla2g2a) [60, 65]. Here, PLA2G2A is linked to neoplasm.