In addition, the concordant promoter methylation of the two studied genes was also investigated (Tables 6 and 7). BRCA1 promoter was methylated in both normal and cancer breast tissue specimens of 11 patients which was statistically significant (p < 0.001), while 20 cases showed combined unmethylation of BRCA1 promoter (Table 6). This evidence concerns the gene BRCA1 and cancer.