LEP and obesity due to melanocortin 4 receptor deficiency: Finally, for the Mantel-Haenszel common OR estimate, IL-6 and leptin were strongly associated with obesity, in patients with either GRS 4 or GRS > 4 (resp., Mantel-Haenszel common OR estimate = 8.77 [95% CI, 2.06–37.44; p = 0.003]; Mantel-Haenszel common OR estimate = 5.76 [95% CI, 1.64–20.24; p = 0.006]).