LEP and obesity due to melanocortin 4 receptor deficiency: We report in Figure 5 that IL-6 and leptin were strongly associated with obesity among patients with GRS 4 (resp., OR = 17.5 [95% CI, 1.56–193.32; p = 0.007]; OR = 16 [95% CI, 1.69–151.11; p = 0.006]).