The NF-κB network plays a crucial role in human health, and aberrant NF-κB activation contributes to the development of a wide range of autoimmune, inflammatory, and malignant disorders, including atherosclerosis, multiple sclerosis, rheumatoid arthritis, inflammatory bowel diseases, and malignant tumors [36, 38, 50]. This evidence concerns the gene NFKB1 and atherosclerosis.