ALB and respiratory failure: The physiopathologic mechanisms of the damage to pulmonary capillary endothelial barrier mainly include the disassembly of tight junction (TJ) and adherens junction (AJ) and reorganization of cytoskeleton, which would enhance pulmonary albumin leak and then result in the extra-vascular leak of the increased albumin leak-induced edema fluid into pulmonary interstitial and alveolar compartments and eventually initiate respiratory failure [5, 6].