Strikingly, retrograde main pancreatic duct injection of 5% sodium taurocholate combined with cecal ligation-perforation successfully induced SAP complicated with endotoxemia (Table 3), the enhancement to systemic and pulmonary albumin leak (Table 4), depravation of airways indicators (Table 5), respiratory dysfunction (Table 5), and also the adverse change in pancreatic and pulmonary tissue pathology (Figure 3), which suggested that the models of ALI caused by endotoxemia in SAP rats were successfully constructed. The gene discussed is ALB; the disease is acute respiratory distress syndrome.