In the present study, real-time PCR (Figure 1) and Western blotting (Figures 2(a) and 2(b)) showed that PPARα was downregulated at the mRNA and protein levels in the S-Cas group compared with the control group (P < 0.01), indicating that myocardial infarction-induced metabolic remodeling involved the suppression of PPARα signaling. This evidence concerns the gene PPARA and myocardial infarction.