The Hb/Hp (Hb and Hb/Hp ColonView Biohit test) complex was positive in 47.1% of the patients with normal colonoscopy, in 50% with hyperplastic polyps, in 54% with adenomas sized <1 cm, in 80% with adenomas sized ≥1 cm, and in 100% with CRC. This evidence concerns the gene HP and colorectal carcinoma.