INS and diabetes mellitus: In total 274 324 (58.4%) of the patients in the study cohort received prescriptions for one or more diabetes drugs during follow-up: 21 308 (4.5%) for glitazones, 32 533 (6.9%) for gliptins, 256 024 (54.5%) for metformin, 134 570 (28.7%) for sulphonylureas, 19 791 (4.2%) for insulin, and 12 062 (2.6%) for other oral diabetes drugs.