Finally, orthotopic xenografts obtained by engrafting WT, PGS and ANXA1 KO MIA PaCa-2 cells in the pancreas of SCID (Severe Combined Immunodeficiency) mice showed that the absence of intracellular ANXA1 did not affected the tumour mass but strongly decreased the metastatization process. The gene discussed is ANXA1; the disease is severe combined immunodeficiency.