The top 15 genes which showed a breakdown of preferential attachment and reduced from high degree genes in germline to tumour include genes such as SORBS2, ZHX2 which have tumour suppression activities62, 63, whereas others such as EIF2S2, ZBTB14 and PPFIA1 promote tumour proliferation and invasion64, 65, 66. The gene discussed is PPFIA1; the disease is neoplasm.