WWTR1 and cancer: Over-expression of TAZ in cultured cells leads to cancer features such as anchorage-independent growth (Chan et al., 2011; Yang et al., 2012), epithelial to mesenchymal transition (EMT) (Chan et al., 2008; Cordenonsi et al., 2011; Hong et al., 2005; Lei et al., 2008), growth-factor-independent proliferation (Yang et al., 2012), resistance to chemotherapeutics (Xu et al., 2015), increased migration, invasion, tumor-initiation properties, and tumor formation in xenograft models (Bartucci et al., 2015; Cordenonsi et al., 2011; Lau et al., 2014; Yuen et al., 2013).