TAZ could be directly phosphorylated by LATS1/2 (the Hippo signaling), Cdk1, GSK3 or c-Abl in different circumstances; subcellular localization of TAZ is controlled by the Hippo signaling pathway in response to a bench of signals; LATS1/2, CK1, and GSK3 contribute to the protein stability regulation of TAZ; a negative feedback loop exists between TAZ and YAP; and the expression of TAZ is modulated by different miRNAs in cancer cells. This evidence concerns the gene LATS1 and cancer.