CDH1 and cancer: However, our preliminary experiments using co-culture of E-cadherin expressing A549 cancer cells with HL-60 derived neutrophil-like cells did not confirm that a simple co-culture can reduce E-cadherin protein level effectively while trypsin protease can degrade E-cadherin ectodomain very effectively in a 2-mintue incubation (Supplementary Fig. 6).