TNF and primary progressive multiple sclerosis: Results showed that: 1) the expression of IL-10 mRNA was increased in PBMCs of HC alone compared to patients with a diagnosis of PP, SP, RR and BE multiple sclerosis (Fig. 7A); and 2) TNFα mRNA was augmented only in PBMC of PPMS patients compared to SPMS, RRMS, BEMS and HC (Fig. 7B).