Exendin-4 (EXD-4), a glucagon-like peptide-1 receptor agonist used for the treatment of type 2 diabetes, and human insulin-like growth factor type 1 (hIGF-1), which is used to treat type 1 and 2 diabetes were expressed under fusion with or without HL28 peptide. The gene discussed is GLP1R; the disease is type 2 diabetes mellitus.