Previous studies in an experimental model of Staphylococcus aureus (S. aureus) induced mastitis have also demonstrated that measuring APP could be useful in identification of the inflammatory response to the mammary infections.10 Although several recent studies on APP in milk during mastitis have focussed on Hp and SAA, some investigations have identified a possible value of bovine milk C-reactive protein (CRP) as a biomarker of bovine mastitis.24–27 However, variation of CRP during the course of an experimental infection has not been previously reported. The gene discussed is HP; the disease is mastitis.