NNMT and cancer: Therefore, concerns regarding the use of 1-MNA in the anticancer therapies that may arise on the basis of recently published NMMT activity in cancer cells seem to be unjustified as pro-metastatic activity of NNMT seems to be related to the intracellular methylation status in cancer cells, while exogenous 1-MNA exerts its anti-inflammatory and anti-thrombotic properties in circulation and thus indirectly affect cancer cells metastasis.