The fifth group of genes (including PTCH1, SHH, ITGA2, ITGA5, GRB2, EP300 and SMC3, listed in Table 6) contribute to the progression of lung adenocarcinoma on at least the microRNA regulation and mRNA expression level (The detailed analysis of the important candidates can be seen in Supplementary Material V). The gene discussed is ITGA2; the disease is lung adenocarcinoma.