NOTCH1 and systemic lupus erythematosus: By comparing the mean β value between NC and SLE (both with LN and without LN involvement), we found that four out of 70 sites on Notch-1 gene, two out of ten sites on IL-17A gene and one out of two sites on IL-2 gene were hypermethylated in SLE (p < 0.05) (data not shown).