Shown in Fig. 4e are the six CpG sites which exhibited the greatest methylation change on the IFN genes between SLE and NC, four on MX1 (cg22862203, cg26312951, cg16785077, cg21549285), one on IFIT3 (cg06188083) and one on IFIT1 (cg05552874) (Fig. 4e). Here, IFNA1 is linked to systemic lupus erythematosus.