Interestingly for the downstream target 4EBP1, there was a main effect of Genotype (F(1, 15) = 5.621, p = 0.05; Fig. 7a, c) where the NonTg mice had increased levels of phosphorylated 4EBP1 compared to 3xTg-AD mice. Here, EIF4EBP1 is linked to Alzheimer disease.