Many polymorphisms have been identified associated with risk of HNSCC by meta-analyses, such as the hOGG1 Ser326Cys polymorphism [9], XRCC1 Arg194Trp polymorphism [10], ERCC2 rs1799793 and rs13181 polymorphisms [11]; however, some polymorphisms including XPD Asp312Asn polymorphism [12], TP53 codon 72 polymorphism [7], and VEGF gene polymorphisms [13] are not associated with HNSCC risk. This evidence concerns the gene ERCC2 and head and neck squamous cell carcinoma.