In the present registry-based study including 3475 consecutively enrolled patients with AMI occurring between 2009 and 2012, we found that several factors such as type of AMI, reduced LVEF, prior stroke, history of no hyperlipidemia, and a low CPK level were strong predictors of a non-invasive therapy independent of age. The gene discussed is PIK3C2A; the disease is hyperlipidemia.