Cutaneous B cell infiltrates from non-malignant skin and melanoma lesion samples were also confirmed by flow cytometric analyses of CD45+CD19+CD22+B cells (Fig. 1d, for matched normal skin and melanoma lesion B cells and peripheral blood B cells from a single donor, representative of n = 4; Figure S2 for further examples of CD45+CD19+B cells from normal skin and melanoma lesion samples). The gene discussed is CD22; the disease is melanoma.