Given multiple variants that exert small effects and the molecular basis of the associations with respect to the complex network underlying the etiology and pathophysiology of T2DM, the present findings require replication in different ethnic populations to clarify the pathological mechanisms by which ZPR1 plays a functional role in T2DM to utilize this gene as a target in clinical practice. The gene discussed is ZPR1; the disease is type 2 diabetes mellitus.