DLTs were observed in 2 patients in each of cohort 1 (grade 4 febrile neutropenia [cycle 2; managed using granulocyte-colony stimulating factor] and grade 3 myalgia [cycle 1; managed using a COX-2 inhibitor]) and cohort 3 (both grade 3 fatigue; cycles 1 and 2). The gene discussed is CSF3; the disease is Myalgia.